Automated Software for AFM force spectroscopy

nanometis provides a technology platform based on the single molecule technique AFM force spectroscopy as an alternative to conventional techniques, such as X-ray crystallography and NMR. nanometis promises to deliver fundamentally new information about biological processes at the level of molecular structure and function. The information derived from traditional methods is limited by their static view, masking the unique properties of their underlying individual molecules. The nanometis technology platform leads to a more direct view of the action of individual molecules without the need to infer the process or function from static structures and is crucial for a better understanding of cellular functions.

Software features

  • Fully automated filtering of included data, removal of corrupt data

  • Fully automated peak detection based on worm - like chain (WLC) model

  • Fully automated alignment: standardization of cantilever binding site on molecule

  • Fully automated detection and clustering of unfolding pathways

  • Integration of public structural information (2D, 3D) from PDB, Uniprot and TMHTT

  • Statistics specialized for single-molecule force spectroscopy (SMFS)

  • Customized reporting of results